Entresto

$160.00$347.00

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Description

Entresto® Overview

Purpose
Entresto is an oral medication approved for the treatment of:

  • Heart Failure with Reduced Ejection Fraction (HFrEF).
  • Heart Failure with Preserved Ejection Fraction (HFpEF) (in many cases).

It helps reduce the risk of hospitalization and death in patients with chronic heart failure by improving heart function and lowering blood pressure.

Mechanism of Action

  • Sacubitril: A neprilysin inhibitor that lowers blood pressure by reducing sodium levels and promoting blood vessel relaxation.
  • Valsartan: An angiotensin II receptor blocker (ARB) that prevents blood vessels from narrowing, improving blood flow.

Together, these agents enhance blood pressure control and overall heart function.


Dosage and Administration

  • Starting Dose: Typically 50 mg or 100 mg twice daily (morning and evening).
  • Adjustment: Dose is adjusted every 2-4 weeks based on response and blood pressure.
  • Target Dose: 200 mg twice daily.
  • Missed Dose: If within a few hours, take the missed dose. Do not double the next dose to compensate.

Administration

  • Can be taken with or without food.

Common Side Effects

  1. Low Blood Pressure (Hypotension): May cause dizziness or light-headedness, especially when standing up.
  2. High Potassium Levels (Hyperkalemia): Detected through blood tests.
  3. Kidney Impairment: Decreased kidney function or renal failure.
  4. Gastrointestinal Issues: Diarrhea, nausea, or gastritis.
  5. Anemia: Reduced red blood cell levels.
  6. Cough and tiredness.
  7. Headache and vertigo.
  8. Low Blood Sugar (Hypoglycemia).

Serious Side Effects

  • Allergic Reactions: Swelling of the face, lips, tongue, or throat (angioedema). These require immediate medical attention.
  • Other Serious Symptoms: Fainting, extreme weakness, or persistent kidney issues.

Precautions

  1. Monitor Potassium and Kidney Function: Regular blood tests may be necessary.
  2. Switching Medications: Ensure a 36-hour gap if switching from or to an ACE inhibitor to reduce the risk of angioedema.
  3. Pregnancy and Breastfeeding: Not recommended; consult a doctor if pregnant or planning to become pregnant.

Patient Advice

  • Always follow your doctor’s prescribed dosage and schedule.
  • Read the manufacturer’s Product Insert for detailed guidance.
  • Report any unusual or persistent side effects to a healthcare provider promptly.
  • Carry the medication’s box and packaging when seeking emergency care.

Disclaimer: This information is for educational purposes only. Consult your healthcare provider before starting or changing medications.

Additional information

Quantity

100mg (49/51), 200mg (97/103), 50mg (24/26)

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Good quality.The product is firmly packed.Good service.Very well worth the money.Very fast delivery.